Bo Liang

2026            Spring    EE 360 Signals and Systems, 3 credits, Role: Instructor

2025            Fall        BME 450/650 Biomedical Instrumentation, 3 credits, Role: Instructor

2025 – 2026 Spring    BME 181 Biomedical Engineering IBL II Cellular physiology, 2 credits, Role: Instructor

2021 – 2025 Fall         EE 490/564 Computational Imaging, 3 credits, Role: Instructor

2021 – 2024 Spring    BME 432/690 Fundamentals of Biomedical Optics, 3 credits, Role: Instructor

2024            Spring    BME 690/444 Advanced imaging systems in biomedicine, 3 credits, Role: Co-Instructor

• Optical imaging and instrumentation
• Neurophotonics
• Neural data processing

2025

• R. Madangopal, Y. Zhao, C. Heins, J. Zhou, B. Liang, G. Barbera, K.C. Lam, L.E. Komer, S.J. Weber, D.J. Thompson, Y. Gera, D.Q. Pham, K.E. Savell, B.L. Warren, D. Caprioli, M. Venniro, J.M. Bossert, L.A. Ramsey, H.P. Jedema, G. Schoenbaum, D. Lin, Y. Shaham, F. Pereira, & B.T. Hope, Distinct prelimbic cortex ensembles encode response execution and inhibition, Proc. Natl. Acad. Sci. U.S.A. 122 (37) e2505378122, (2025).
• Hawes, S., Liang, B., Oldham, B., Sullivan, B. T., Wang, L., Song, B., ... & Cai, H. (2025). Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence. eLife, 2025-02.
• Sandhu, S. S., Denny, D. L., Owens, R. A., Jean, K. L., Liang, B., Fakir, M. H., ... & Tavakolian, P. (2025). Evaluating alternating pressure air mattress effectiveness through the measurement of skin redness and blood perfusion. Journal of Tissue Viability, 34(3), 100904.
• Maisumu, G., Willerth, S., Nestor, M.W., Waldau, B., Schülke, S., Nardi, F.V., Ahmed, O., Zhou, Y., Durens, M., Liang, B. and Yakoub, A.M. (2025). Brain organoids: Building higher-order complexity and neural circuitry models. Trends in biotechnology, 43(7), pp.1583-1598.
• Aliee, M., Gorji, H. T., Vasefi, F., Yaggie, K., Qin, J., Baek, I., ... & Liang, B. (2025). GLOW-DL: generalized light-optimized workflow with deep learning for contamination detection using fluorescence imaging in variable conditions. Journal of Biosystems Engineering, 1-15.

2024

• Ahmed, O., Ekumi, K. M., Nardi, F. V., Maisumu, G., Moussawi, K., Lazartigues, E. D., Liang, B., & Yakoub, A. M. (2024). Stable, neuron-specific gene expression in the mouse brain. Journal of biological engineering, 18(1), 8.
• Glanzberg, J. T., Denman, A. J., Beacher, N. J., Broomer, M. C., Liang, B., Li, Y., ... & Lin, D. T. (2024). Individual differences in prelimbic neural representation of food and cocaine seeking. Cell reports, 43(12).
• Nardi, F. V., Maisumu, G., Zhou, Y., Liang, B., & Yakoub, A. M. (2024). Protocol for generation of PD modeling induced neurons and detection of α-synuclein forms. STAR protocols, 5(4), 103447.

2022

• Barbera, G., Jun, R., Zhang, Y., Liang, B., Li, Y., & Lin, D. T. (2022). A miniature fluorescence microscope for multi-plane imaging. Scientific reports, 12(1), 1-8.
• Liang, B., Thapa, R., Zhang, G., Moffitt, C., Zhang, Y., Zhang, L., ... & Li, Y. (2022). Aberrant Neural Activity in Prefrontal Pyramidal Neurons Lacking TDP-43 Precedes Neuron loss. Progress in Neurobiology, 102297.
• Liang, B., Zhang, L., Zhang, Y., Werner, C.T., Beacher, N.J., Denman, A.J., Li, Y., Chen, R., Gerfen, C.R., Barbera, G. and Lin, D.T., 2022. Striatal direct pathway neurons play leading roles in accelerating rotarod motor skill learning. iScience, p.104245.
• Zhang, Y., Denman, A.J., Liang, B., Werner, C.T., Beacher, N.J., Chen, R., Li, Y., Shaham, Y., Barbera, G. and Lin, D.T., 2022. Detailed mapping of behavior reveals the formation of prelimbic neural ensembles across operant learning. Neuron, 110(4), pp.674-685.

2021

• Thapa R, Liang B, Liu R, Li Y. Stereotaxic Viral Injection and Gradient-Index Lens Implantation for Deep Brain In Vivo Calcium Imaging. J Vis Exp. 2021 Oct 8;(176). doi: 10.3791/63049. PMID: 34694282.

2020

• Barbera G., Zhang Y., Werner C., Liang B., Li Y., Lin D-T (2020). An open source motorized swivel for in vivo neural and behavioral recordings. MethodsX, 7, 101167. 
• Barbera G., Liang B., Zhang Y., Moffitt C., Li Y., Lin D-T (2020). An open-source capacitive touch sensing device for three chamber social behavior test. MethodsX, 7, 101024. 

2019

• Wu J., Kung J., Dong J., Chang L., Xie C., Habib A., Hawes S., Yang N., Chen V., Liu Z., Evans R., Liang B., Sun L., Ding J., Yu J., Saez-Atienzar S., Tang B., Khaliq Z., Lin D-T., Le W., Cai H (2019). Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Reports 28(5): 1167-1181.e7.
• Barbera G., Liang B., Zhang L., Li Y., Lin D.T. (2019). A wireless miniScope for deep brain imaging in freely moving mice. J Neurosci Methods 323, 56-60.
• Liang, B. *, Zhang, L. *, Moffitt, C., Li, Y., and Lin, D.T. (2019). An Open-source Automated Surgical Instrument for Microendoscope Implantation. J Neurosci Methods 311, 83-88. (*Corresponding authors)
• Yang, Y., Zhang, L., Wang, Z., Liang, B., Barbera, G., Moffitt, C., Li, Y., and Lin, D.T (2019). A Two-Step GRIN Lens Coating for in vivo Brain Imaging. Neuroscience Bulletin 1-6.

2018

• Liang, B.*, Zhang, L.*, Barbera, G., Fang, W., Zhang, J., Chen, X., Chen, R., Li, Y., and Lin, D.T. (2018). Distinct and Dynamic ON and OFF Neural Ensembles in the Prefrontal Cortex Code Social Exploration. Neuron 100, 700-714.e9. (*Co-first authors) [ Neuron preview; NIDA news]
• Zhang, L. *, Liang, B. *, Barbera, G. *, Hawes, S., Zhang, Y., Stump, K., Baum, I., Yang, Y., Li, Y., and Lin, D.T. (2018). Miniscope GRIN Lens System for Calcium Imaging of Neuronal Activity from Deep Brain Structures in Behaving Animals. Curr Protoc Neurosci, e56. (*Co-first authors)

2017

• Zhang W, Daly KM, Liang B, Zhang LF, Li, X, Li Y, Lin DT. (2017). BDNF Rescues Prefrontal Dysfunction Elicited by Pyramidal Neuron Specific DTNBP1 Deletion In Vivo. J Mol Cell Biol 9(2):117-131.
• Zhang, L., Liang, B., Li, Y. and Lin, D. (2017). Thinned-skull Cranial Window Preparation (Mice). Bio-protocol7(5): e2158.

2016

• Barbera G*, Liang B*, Zhang LF*, Gerfen CR, Culurciello E, Chen R, Li Y, Lin DT (2016). Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information. Neuron 92(1):202-213 (*Co-first authors) [NIDA news; Neuron Video Abstract Featured]
• Zhang W*, Zhang LF*, Liang B, Schroeder D, Zhang ZW, Cox GA, Li Y, Lin DT (2016). Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders. Nature Neuroscience 19, 557–559. [News highlights]

Before 2014

• Liang B, Dai Y, Zhao HX, Zhang YD (2013). Effect of Ocular Aberrations on Binocular Summation in Different Light Levels. Opto-Electronic Engineering 40(7): 1-8.
• Yang, B, Liang, B, Liu, L, Liao, M, Li, Q, Dai, Y, Zhao, HX, Zhang, Y., & Zhou, Y. (2013). Contrast Sensitivity Function after Correcting Residual Wavefront Aberrations during RGP Lens Wear. Optometry & Vision Science 91(10):1271-7.
• Liang, B, Liu, R, Dai, Y, Zhou, JW, Zhou, YF, & Zhang, YD (2012). Effects of Ocular Aberrations on Contrast Detection in Noise. Journal of Vision, 12(8):3, 1–15.
• Zhou, JW, Zhang, YD, Dai, Y, Zhao, HX, Liu, R, Hou, F., Liang, B, Hess, RF & Zhou, YF (2012). The Eye Limits the Brain’s Learning Potential. Scientific Reports 2, 364.