Gunjan Manocha

Peer Reviewed Publications

1. Jurivich DA, Van Eck R, Wood JR, Snustad D, Holloway J, Landgendoen D, Hughes M, Galynker B, Brewster S, Manocha GD, A Geriatric Game to Strengthen Older Adult Health Care: Delivery and Outcomes, Journal of American Geriatrics Society, 2024, conditionally accepted
2. Trivedi R, Knopf B, Rakoczy S, Manocha GD, Borwn-Borg H, Disrupted HSF1 regulation in normal and exceptional brain aging, Biogerontology, 2023.
3. Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H, Multifactorial Attenuation of the Murine Heat Shock Response With Age, The Journals of Gerontology: Series A, 75 (10), October 2020, 1846–1852
4. Sohrabi M, Floden AM, Manocha GD, Klug MG and Combs CK (2020) IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model. Front. Cell. Neurosci. 14:200. doi: 10.3389/fncel.2020.00200
5. Jurivich D, Manocha GD, Opinion- Is Twitter the new way to learn? Journal of Investigative Surgery, 2019, 6, 1-2
6. Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK, Temporal Progression of Alzheimer’s Disease in Brains and Intestines of Transgenic Mice, Neurobiology of Aging, 2019, 81, 166-176.
7. Kulas JA, Franklin W, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK, Ablation of Amyloid Precursor Protein Increases Insulin Degrading Enzyme Levels and Activity in Brain and Peripheral Tissues, Am J Physiol Endocrinol Metab. 2018 Nov 13. doi: 10.1152/ajpendo.00279.2018
8. Manocha GD, Ghatak A, Puig KL, Combs CK, Anti-α4β1 integrin antibodies attenuated brain inflammatory changes in a mouse model of Alzheimer’s disease, , Current Alzheimer’s Research, July 2018
9. Kulas JA, Hettwer J, Sohrabi M, Melvin J, Manocha GD, Puig KL, Gorr M, Tanwar V, McDonald M, Wold L, Combs CK, In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice, , Environmental Pollution, 2018, 241, 279
10. Floden AM, Sohrabi M, Nookala S, Manocha GD, Combs CK, Differences in salivary Aβ levels and oral microflora in Alzheimer’s Disease mourse models, Alzheimer's & Dementia 14 (7S_Part_5), P311-P311.
11. Manocha GD, Ghatak A, Puig KL, Kraner SD, Norris CM, Combs CK, NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer’s Disease, Journal of Alzheimer’s Disease, 2017, 58, 775
12. Manocha GD, Floden AM, Puig KL, Nagamoto-Combs K, Scherzer CR, Combs CK, Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice, Molecular Neurodegeneration, 2017, 12, 17
13. Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee J, Puig KR, Puig KL, Karki S, Nichols MR, Darland DC, Porter JE, Combs CK, APP regulates microglial phenotype in a mouse model of Alzheimer’s disease, J. Neuroscience, 2016, 36, 8471
14. Nagamoto-Combs K, Manocha GD, Puig KL, Combs CK, An improved approach to align and embed multiple brain samples in a gelatin-based matrix for simultaneous histological processing, J Neurosci Methods, 2016, 261, 155
15. Manocha GD, Puig KL, Austin SA, Seyb K, Glicksman MA, Combs CK, Characterization of novel Src family of kinase inhibitors to attenuate microgliosis, Plos One 2015, 10, 10
16. Puig KL, Lutz BM, Urquhart SA, Rebel AA, Zhou X, Manocha GD, Sens M, Tuteja AK, Forster NL, Combs CK, Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System., J Alzheimer’s Dis, 2015, 44(4), 1263
17. Rojanathammanee L, Floden A, Manocha GD, Combs CK, Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition, J Neuroinflammation, 2015, 12(1), 42
18. Puig KL, Manocha GD, Combs CK, Amyloid Precursor Protein Mediated Changes in Intestinal Epithelial Phenotype in Vitro, Plos One, 2015, 10(3)
19. Manocha GD, Mishra R, Sharma N, Kumawat KL, Basu A, Singh SK, Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells, J Neuroinflammation, 2014, 11, 24
20. Dhawan G and Combs CK, Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer’s disease, J Neuroinflammation, 2012, 9(1), 117
21. Dhawan G, Floden A, Combs CK, Amyloid beta oligomers stimulate microglia through a tyrosine kinase dependant mechanism, Neurobiology of Aging, 2011, 33, 2247
22. Sondag CM, Dhawan G, Combs CK, Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia, J Neuroinflammation. 2009, 6, 1
23. Dhawan G, Sumana G, Malhotra BD, Recent developments in urea biosensors, Biochemical Engineering Journal, 2009, 44, 42

Peer Reviewed Abstracts and presentations as Research Mentor

1. Holzwarth E, Knutson P, Soultan E, Hara A, Klug M, Manocha GD, Jurivich D, Blood Pressure Variability Associated with Falls in Nursing Home Residents, Journal of American Geriatrics Society, 2024, 72, S1.
2. Knutson P, Holzwarth E, Carr P, Van Eck R, Manocha GD, Jurivich D, Flipping the Anatomy Lab for Geriatrics Knowledge, Journal of American Geriatrics Society, 2024, 72, S1.
3. Marterns L, Virgin N, Hoffarth P, Derenne N, Van Eck R, Manocha GD, Jurivich DArtificial Intelligence Recapitulates Ageism Inherently Expressed in Society, Journal of American Geriatrics Society, 2024, 72, S1.
4. Ohman E, Bakkum C, Gibbons J, Thompson S, Holloway J, Manocha GD, Jurivich D, Health Promotion for Under-resourced Populations through an Interprofessional Community Service-Learning Project, Journal of American Geriatrics Society, 2024, 72, S1.
5. Anderson E, Holloway J, Reed B, Green N, Dahl L, Manocha GD, Jurivich D, Trainee Responses to Asynchronous Online Geriatrics Curriculum, Journal of American Geriatrics Society, 2024, 72, S1.
6. Manocha GD, Derenne N, VanEck R, Jurivich D, Artificial Intelligence Perpetuates Ageism via Imagery Selection, Journal of American Geriatrics Society, 2023, 71, S1.
7. Martens L, Manocha GD, Dahl L, Wegner N, Ness M, Jurivich D, Integrating a curriculum for caregivers of people living with dementia into PCMH: CaRE (Caregiver Resources and Education), Journal of American Geriatrics Society, 2023, 71, S1.
8. Manocha GD, Wegner N, Binger K, Dahl L, Jurivich D, C.A.R.E. (Caregiver Resources and Education): A Curriculum for Caregivers of People Living With Dementia, Journal of American Geriatrics Society, 2022, 70, S1.
9. Manocha GD, Wong C, Dahl L, Chapman E, Zietlow K, Vitale C, Rentsch S, Pellecer D, Tung E, Kaur T, Sreedhar R, Leung V, Jurivich D, @GeriatricsJC: Twitter Journal Club Improves Geriatric Fellowship Program collaborations, Journal of American Geriatrics Society, 2022, 70, S1.
10. Snustad D, Wood JR, Morton C, Brewster S, VanEck RN, Manocha GD, Jurivich D, GeriPop: A Game to Apply the 4Ms to Patient Populations, Journal of American Geriatrics Society, 2022, 70, S1.
11. Jurivich D, Manocha GD, Pandemic paralysis: Stunted Geriatrics Knowledge Acquisition, Journal of American Geriatrics Society, 2021, 69, S1.
12. Ali SH, Manocha GD, Jurivich D, Mini Geriatric Medicine clerkship for MS3, Journal of American Geriatrics Society, 2021, 69, S1.
13. Soultan E, Hara A, Morton C, Klug M, Manocha GD, Jurivich D, Blood pressure variability is associated with falls in long term care, Journal of American Geriatrics Society, 2021, 69, S1.
14. Wood JR, Morton C, Holloway J, Brewster S, Manocha GD, VanEck R, Jurivich D, Older Adults Population Health Serious Game, Journal of American Geriatrics Society, 2021, 69, S1.
15. Bau H, Morton C, Derenne N, Manocha GD, Jurivich D, Use of Social Media as an Educational Platform, Journal of American Geriatrics Society, 2021, 69, S1.

Other accepted Abstracts, poster and oral and Presentations:

1. Bijayani Sahu, Mona Sohrabi, Angela Floden, Alexandra Mclntee, Gunjan Manocha, Suba Nookala and Colin Combs, Splenectomy alters amyloid load, microglial phenotype, and cytokine levels in male mouse models of Alzheimer’s Disease, Society for Neuroscience, Annual Meeting, 2023
2. Bijayani Sahu, Mona Sohrabi, Angela Floden, Gunjan Manocha, Suba Nookala, Colin Combs; Splenectomy reduces Aβ plaque load ameliorating the Alzheimer’s pathology potentially by increasing beneficial neuro-inflammatory cycle, Poster Presentation, Society for Neuroscience (SFN) Annual Meeting (2020).
3. Angie M. Floden, Mona Sohrabi, Suba Nookala, Gunjan D. Manocha, Colin K. Combs; Comparison of salivary Aβ levels and oral microbiome in two different mouse models of AD, Poster Presentation, Society for Neuroscience (SFN) Annual Meeting (2019) Chicago.
4. Rachana Trivedi, Donald Jurivich, Gunjan Manocha, Mary Lizakowski, Rakoczy Sharlene, HollyBrown-Borg, Multi-factorial attenuation of the murine heat shock response with age, Poster presentation, Frank Low Research Day (2019), UND, Grand Forks.
5. Gunjan D. Manocha, Angela M. Floden, Nicole M. Miller, Abbie Smith, Kumi Nagamoto-Combs, Takashi Saito, Takaomi C. Saido, Colin K. Combs, Defining the temporal progression of Alzheimer’s disease in the brain vs. intestine using APP/PS1 and APP (NL-G-F) mice, oral/poster presentation at the Alzheimer’s Association International Conference (AAIC), 2018, Chicago.
6. Gunjan D. Manocha, Angela M. Floden, Nicole M. Miller, Abbie Smith, Kumi Nagamoto-Combs, Takashi Saito, Takaomi C. Saido, Colin K. Combs, Defining the temporal progression of Alzheimer’s disease in the brain vs. intestine, poster presentation at the Society for Neuroscience (SFN) meeting, 2017, Washington DC.
7. Gunjan D Manocha, Contribution of Neuroinflammation to Parkinson's Disease in Humanized Immune System Mice, oral presentation at the North Dakota Academy of Sciences Meeting, 2017, Grand Forks
8. Nicole Miller, Gunjan Manocha, Colin Combs, Defining the temporal relationship between Aβ plaque deposition and reactive gliosis in Alzheimer’s Disease, poster presentation, Frank Low Research Day, UND, 2016
9. Megan Braun, Gunjan Dhawan, Colin K. Combs, Comparing Mouse Models for Alzheimer’s disease Pathology in the Brain and Small Intestine, poster presentation, REU program, UND, 2016
10. Gunjan D Manocha, Joshua A. Kulas, Thomas N. Seyfried, Colin K. Combs, Microglial properties of glioblastoma as potential therapeutic targets, poster presentation at the Society for Neuroscience (SFN) meeting, 2016, San Diego
11. Gunjan Dhawan Manocha, Kendra L. Puig, Susan A. Austin, Kathleen Seyb, Marcie A. Glicksman, Colin K. Combs Characterization of novel Src family kinase inhibitors to attenuate microgliosis, poster presentation at the Society for Neuroscience (SFN) meeting, 2015, Chicago
12. Gunjan D Manocha, Kendra L Puig, Colin K Combs, Contribution of Neuroinflammation to Parkinson's Disease in Humanized Immune System Mice, poster presentation at the Society for Neuroscience (SFN) meeting, 2015, Chicago
13. Gunjan Dhawan Manocha, Angela M. Floden, Keiko Rausch, Lalida Rojanathammanee, Kelley R. Puig, Kendra L. Puig, Colin K. Combs, Amyloid Precursor Protein Regulates Microglial Phenotype in a Mouse Model of Alzheimer’s Disease, poster presentation at the Society for Neuroscience (SFN) Meeting, 2014, Washington DC.
14. Gunjan Dhawan Manocha, Angela M. Floden, Keiko Rausch, Lalida Rojanathammanee, Kelley R. Puig, Kendra L. Puig, Colin K. Combs, Amyloid Precursor Protein Regulates Microglial Phenotype in a Mouse Model of Alzheimer’s Disease, poster presentation at the American Society for Neurochemistry (ASN) Meeting, 2014, Long Beach CA.
15. Gunjan Dhawan and Colin Combs, Role of Src-kinase in amyloid dependant microgliosis in Alzheimer’s disease, poster presentation at the Society for Neuroscience (SFN) Meeting, 2011, Washington DC.
16. Gunjan Dhawan and Colin Combs, dasatinib as a novel anti-inflammatory therapy for treating Alzheimer’s disease, poster presentation at the American Society for Neurochemistry (ASN) Meeting, 2011, St. Louis.
17. Gunjan Dhawan and Colin Combs, A novel anti-inflammatory therapy for treating Alzheimer’s disease, oral presentation at the Graduate Scholarly Forum, 2011, UND.
18. Siri Urquhart, Gunjan Dhawan, Colin K. Combs, Comparison of APP and Aβ Deposition in the Ileum and Brain of an AD Mouse Model, poster presentation, REU program, UND, 2011.
19. Gunjan Dhawan, Angie Floden and Colin Combs, Oligomer Amyloid-β stimulates tyrosine-kinase dependent microgliosis in Alzheimer’s disease, poster presentation at the Society for Neuroscience (SFN) Meeting, 2010, San Diego.
20. Gunjan Dhawan and Colin Combs, Non-Receptor tyrosine kinase activity modulates microglial phenotype in Alzheimer’s disease, poster presentation at NDEPSCoR Meeting, 2010, Grand Forks.
21. Gunjan Dhawan and Colin Combs, Non-Receptor tyrosine kinase activity modulates microglial phenotype in Alzheimer’s disease, poster presentation at Neuroscience Symposium, COBRE Meeting, 2010, Grand Forks.
22. Gunjan Dhawan and Colin Combs, Role of oligomer Aβ in tyrosine-kinase dependent stimulation of microglia in-vivo, oral presentation at the North Dakota Academy of Sciences Meeting 2010, Minot, ND.
23. Gunjan Dhawan, Angie Floden and Colin Combs, Role of oligomer Aβ in tyrosine-kinase dependent stimulation of microglia in-vivo, poster presentation at Frank Low Research Day, 2010, UND School of Medicine and Health Sciences.
24. Sheryl Delude, Gunjan Dhawan, Colin K. Combs, Beta-Amyloid oligomer stimulated increases in tyrosine kinase phosphorylation in primary microglia and microglia cell line, poster presentation, REU program, UND, 2009
25. Gunjan Dhawan and Colin Combs, Aβ-oligomer stimulates microglia through tyrosine kinase dependant pathway, poster presentation at 39th Society for Neuroscience Meeting, 2009, Chicago.
26. Gunjan Dhawan and Colin Combs, Aβ-oligomer stimulates microglia through tyrosine kinase activation in-vitro, poster presentation at Frank Low Research Day, 2009, UND School of Medicine and Health Sciences.
27. Gunjan Dhawan and Colin Combs, Amyloid-β oligomer stimulates microglia through a tyrosine kinase dependent-pathway, abstract submission for North Dakota Academy of Sciences Meeting 2009.
28. Gunjan Dhawan and B.D. Malhotra, Applications of nanostructured conducting polymers to biosensor, poster presentation at Science Day, 2007, National Physical Laboratory, New Delhi.

• 2010 - 2012 ND EPSCoR Doctoral Dissertation Assistantship (DDA)
• 2011 “Young Investigator’s Educational Enhancement” Travel Award by American Society for Neurochemistry (ASN).
• 2010 Summer Doctoral Fellowship by UND Graduate School.
• 2010 A. Roger Denison Award for oral presentation, Role of oligomer A? in tyrosine-kinase dependent stimulation of microglia in-vivo, at the North Dakota Academy of Sciences Meeting, Minot, ND.
• 2006 CSIR-UGC (NET) (India) Junior Research Fellowship (JRF) and Lectureship (LS) in Chemical Sciences.

2007-2011       Ph.D                                      Department of Pharmacology, Physiology and Therapeutics, UND

2004-2006       Masters of Science                  Indian Institute of Technology (IIT Delhi), New Delhi, India

                       (M.Sc) Chemistry                               

 2001-2004      Bachelors of Science                 Sri Venkateswara College, University of Delhi, Delhi, India

                       (B.Sc) Chemistry (Honors)

2018- Present  Assistant Professor, Department of Geriatrics, University of North Dakota

2018- Present  Director of Geriatric Education, Department of Geriatrics, University of North Dakota

2019- Present  Associate Program Director, Dakota Geriatrics (HRSA-GWEP)

2014-2018       Post-Doctoral Fellow, Department of Biomedical Sciences, University of North Dakota

2013-2014       Research Associate, Centre for Cellular and Molecular Biology, Hyderabad, India                    

2007-2011       Graduate Research Assistant, School of Medicine and Health Sciences, University of North Dakota, ND